An Iranian demonstrator ignites a flare as others carry a Palestinian flag during an anti-Israeli gathering in Tehran on Sunday. (Vahid Salemi/AP)
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ISTANBUL — After Iran launched a retaliatory wave of missiles and drones toward Israel, a rare direct attack by Tehran, much of the Middle East found itself in uncharted territory: bracing for further violence while scrambling to interpret the new rules of confrontation between the region’s most powerful adversaries.

Iranian-backed militant groups that have participated in attacks on Israel over the last six months — in Yemen, Lebanon, and Iraq — congratulated Iran for the barrage but indicated that, this time, they had largely stayed out of the fray.